The Relationship Between AKR1B1 rs759853 (C-106T) Polymorphism and the Diabetic Retinopathy Severity in Turkish Type 2 Diabetes Mellitus Patients

Aim: Diabetes mellitus (DM) is an important health problem with increasing incidence worldwide and causes many complications. Diabetic retinopathy (DR) one of the most serious complications DM. Polymorphisms AKR1B1 gene, which encodes aldose reductase enzyme, have been associated development DM DR in some studies. The current study aims to investigate relationship rs759853 polymorphism type 2 (T2DM), severity Turkish population. Materials Methods: A total 437 individuals, including 141 T2DM patients without DR, 125 171 healthy controls, were included study. Genotyping was performed using PCR-RFLP method.Results: An association between T allele / TT genotype increased risk proliferative diabetic (PDR) detected. In logistic regression analysis other factors included, diabetes duration found be PDR development. There no significant variation DR. Conclusion: Obtained data showed that not patients, but are independent for PDR.